Influence of Ionizing Radiation on the Allergic Reactivity of Tuberculosis-Infected Laboratory Animals

Allergic examination using PPD-tuberculins is the main method of life-time tuberculosis diagnostics in farm animals and poultry. However, it known about a decrease diagnostic value allergic reactions after irradiation animals, occurrence non-specific, pseudo-allergic reactions. One reasons for manifestation non-specific may be autosensitisation (autoallergisation) body by breakdown products personal tissues, which especially pronounced with radiation damage. Ionizing affects tuberculin sensitivity, course autoimmune processes body. Differential remains not yet fully solved problem, although there are many tests its implementation. After accident at Chernobyl nuclear power plant, considerable number remained adjacent territories contaminated radioactive substances, including those infected causative agent atypical mycobacteria. It that leads to own tissues development pseudoallergic heterologous allergens. Therefore, work was carried out study reactivity patients laboratory sensitised mycobacteria irradiated gamma (200 guinea pigs). established 14-60 days infection pathogens, 90-100% cavies developed PPD-tuberculin mammals poultry, mainly homologous allergen. persisted until 90 study. exposure sublethal (non-lethal) doses rays, intact allergens: mallein brucellin. In uninfected tuberculosis, 7 exposure, mycobacterial allergens were observed dose load 200 R 16.6%; 150 – 5.3% group, 27 50 100 25% 33% studied respectively. Isolated brucellin occurred 60 R, R. The allergies depended on rate radiosensitivity